Acting Head: dr n. med. Agnieszka Paradowska-Gorycka
Team: dr n. med. Anna Wajda, mgr biotech. Barbara Stypińska, mgr Agnieszka Grzybowska-Kowalczyk, mgr inż. Ewa Walczuk
Technical staff: Wiesława Frankowska, Teresa Gołaszewska


Main tasks:

  1. Research on chronic inflammation
  2. Molecular studies on chronic rheumatic diseases:
  • getting to know the nature of the defect of rheumatic diseases and the correlation between the clinical picture and the genotype of the disease
  • molecular pathology
  • studying microRNA functions, where impaired expression may lead to alterations initiating the inflammation process
  • the assessment of the circulating and intracellular miRNA profile in patients with rheumatoid arthritis, systemic lupus erythematosus, MCTD and TU
  • studying miRNA interactions: mRNA
  • modulations of the balance/differentiation/the amount of T cells
  • the impact of genetic variants of transcription factors and cytokines on the Treg/Th17 balance
  • the analysis of the function and the meaning of dendritic cells
  • the assessment of the cytokine profile in rheumatic patients


Grants at the Molecular Biology Department:

1) „The analysis of intracellular and circling microRNA connected with the balance of Treg and Th17 cells in patients with rheumatoid arthritis” (Project Manager dr n med. Agnieszka Paradowska-Gorycka, project duration: 2016-2019), financed by: the National Science Center (OPUS)

2) „Genetic and epigenetic differences in the U1-RNP/TLRs/IFN signaling pathway in the pathogenesis and clinical picture of the mixed connective tissue disease (MCTD)” (Project Manager dr n med. Agnieszka Paradowska-Gorycka, project duration: 2016 – 2018), financed by the Scientific Foundation of Polpharma

Projects of the Molecular Biology Department being a part of statutory programs of the National Geriatrics, Rheumatology and Rehabilitation Institute during the past 5 years

1) S/13 “The contribution of genetic factors to the pathogenesis and the clinical picture of inflammatory connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus, MCTD)”; project duration 2015-2017;

2) “Studying the contribution of cellular mediators of inflammatory reaction in the development of acquired and congenital immunity”; project duration 2012-2014;

3) “The role of the redox potential in the interaction neutrophilic leucocyte – microphag cultured in the joint fluid of patients with rheumatoid arthritis”; project duration 2015-2017;

4) “Immunological and genetic determinants of the development of the Sjögren-syndrome”; project duration 2012-2014;

5) “The assessment of the impact of immunological and genetic factors on the development of atheromatosis in patients with systemic lupus erythematosus, the mixed connective tissue disease and the antiphospholipid syndrome”; project duration 2015-2017.


PhDs, postdoctoral degrees, professorships:

  • doctoral dissertations – 11
  • habilitation dissertations – 2
  • professorial titles – 1

Biochemistry and Molecular Biology Department
Spartańska street 1
02-637 Warsaw
phone: +48 22 670 91 90
e-mail address: zaklad.biochemii@spartanska.pl