Pathophysiology and Immunology Department

Head: prof. dr hab. n. biol. Włodzimierz Maśliński

Deputy Head: prof. dr hab. n. med. Ewa Kontny, Associate Prof. of the National Geriatrics, Rheumatology and Rehabilitation Institute

Researchers: dr n. med. Weronika Kurowska (Assistant Professor), dr n. med. Ewa Kuca-Warnawin (Assistant Professor), dr n. med. Magdalena Massalska (Assistant), dr Marzena Ciechomska (Assistant Professor), dr n. med. Urszula Skalska (Assistant Professor), mgr biol. Anna Radzikowska (Assistant).

Engineering and technical employee: mgr biol. Magdalena Plebańczyk.

Technical employees: mgr Iwona Janicka, mgr Tomasz Burakowski, st. techn. Anna Kornatka, st. techn. Urszula Musiałowicz.

Secretariat: Grażyna Korolkiewicz.

Main tasks:

• • assessing immunological parameters characteristic for patients suffering from rheumatoid arthritis in the undifferentiated arthritis phase
  • the mechanisms of dysregulated production of key maturation modulators and modulators of the activation of osteoclasts taking part in bone destruction
  • immunomodulatory and regenerative characteristics of mesenchymal stem cells (MSC) of the adipose tissue in patients with rheumatoid arthritis and osteoarthritis
  • quantitative and functional disorders of regulatory lymphocytes in patients with rheumatoid arthritis
  • the impact of the articular and extra-articular adipose tissue on autoimmune disorders in rheumatoid arthritis
  • studying synovial cells of the fibroblast type and their role in the destruction of joint structures
  • the participation of the bone marrow in the initiation and maintenance of chronic inflammation in rheumatoid arthritis
  • disorders of the production of cytokines and their impact on the activation of cells of the immune system and beyond
  • immunosuppressive characteristics of taurine chloramine
  • immunological mechanisms related to arthritis occurring together with other diseases (nonspecific enteritis, sarcoidosis)
  • looking for non-invasive diagnostic methods useful in the early diagnosis of enteritis in the course of spondyloarthropathy
  • immunological disorders in the Sjögren-syndrome
  • immunological disorders in the mixed connective tissue disease

• Grants of the past 5 years
• Ongoing:
  • 2017-2019 Functional characteristics of mesenchymal stem cells derived from the adipose tissue of patients suffering from rheumatic diseases in terms of their therapeutic use. OPUS 11, National Scientific Center (Project Manager dr hab. n. med. prof. nadzw. Ewa Kontny)
  • 2016-2018 The influence of mesenchymal stem cells from the intra-articular adipose tissue on the activation state and the differentiation of T- lymphocytes in rheumatoid arthritis. SONATA 9, National Scientific Center (Project Manager dr n. med. Urszula Skalska)
  • 2015 – 2018 A global miRNA analysis in monocytes of patients with rheumatoid arthritis and systemic scleroderma. Fuga 4, National Scientific Center (Project Manager dr Marzena Ciechomska)
  • 2013 – 2017 Immunological and radiological parameters, characteristic for patients with rheumatoid arthritis – undifferentiated arthritis. National Scientific Center (Project Manager prof. dr hab. Włodzimierz Maśliński)
  • 2013 – 2018 A comparative assessment of the biological intra-articular activity of the adipose tissue of patients with rheumatoid arthritis and osteoarthritis. National Scientific Center (Project Manager mgr Magdalena Plebańczyk, scientific supervisor of the project dr hab. n. med. prof. nadzw. Ewa Kontny)
• Finished:
  • 2012 – 2017 The contribution of bone marrow with particular emphasis on the population of cells producing Il-17 to the pathogenesis of rheumatoid arthritis. National Scientific Center (Project Manager dr n. med. Ewa Kuca-Warnawin)
  • 2013-2016 The influence of B-lymphocytes on the clinical picture of the primary Sjögren syndrome – an immunohistochemical and serological evaluation as well as an evaluation of cytokine profiles regulating the activity of these cells. National Scientific Center (Project Manager lek. Maria Maślińska, scientific supervisor of the project dr hab. n. med. prof. nadzw. Ewa Kontny)
  • 2013-2016 Determination of the profile of cytokines related to arthritis in the course of nonspecific enteritis. National Scientific Center (Project Manager lek. Joanna Dmowska-Chalaba, scientific supervisor of the project dr hab. n. med. prof. nadzw. Ewa Kontny)
  • 2013 – 2015 The development of innovative genetic tests based on the NGS technology. National Research and Development Center (Project Coordinator DNA Research Center Sp. z o. o.)
  • 2011 – 2014 Immunomodulatory characteristics of mesenchymal stem cells isolated from the intra-articular adipose tissue of patients with rheumatoid arthritis. National Scientific Center (Project Manager mgr Urszula Skalska, scientific supervisor of the project dr hab. n. med. prof. nadzw. Ewa Kontny)
  • 2010 – 2013 The role of the adipose tissue in rheumatoid arthritis. National Scientific Center (Project Manager dr hab. n. med. prof. nadzw. Ewa Kontny)

PhDs, postdoctoral degrees, professorships:

• doctoral dissertations – 25
• habilitation dissertations – 7
• professorial titles – 5

Contact
Pathophysiology and Immunology Department
Spartańska street 1
02-637 Warsaw

phone: +48 22 670 92 60
e-mail address: zaklad.patofizjologii@spartanska.pl
Secretariat
e-mail address: grazyna.korolkiewicz@spartanska.pl

Head of the Department
prof. dr hab. Włodzimierz Maśliński
e-mail address: wlodzimierz.maslinski@spartanska.pl

Deputy Head
dr hab. n. med. Ewa Kontny, Associate Prof. of the National Geriatrics, Rheumatology and Rehabilitation Institute
e-mail address: ewa.kontny@spartanska.pl